KMID : 0370220020460040231
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Yakhak Hoeji 2002 Volume.46 No. 4 p.231 ~ p.236
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Simultaneous HPLC Determination of Preservatives in Cosmetics
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Yang Seong-Jun
Kim Young-Ok Son Kyung-Hun Lee Jeong-Pyo Jeong Rae-Seok Yang Won-Jun Paek Ock-Jin Lee Hyun-Kyung Choi Sang-Sook
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Abstract
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A high-performance liquid chromatographic method for the simultaneous quantitative analysis of methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP) and imidazolidinyl urea(IU) or diazolidinyl urea(DU) in cosmetics was studied by using a cyano-propyl column and 0.05M hexanesulfonic acrid at 228 nm. Calibration curves were found to be linear in the 60-1000 g/mL range (parabens), 100-1,250 gg/mL range (RD and the 120-2000 g/ mL range (DU). Linear regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy. An extraction method is developed and validated in order to apply this chromatographic, method to a commercial cosmetic cream. The precision of this method, calculated as the relative standard deviation (RSD) of the recoveries (0.46-2.71%) was excellent for all compounds.
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KEYWORD
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Imidazolidinyl urea, diazolidinyl urea, paraben, HPLC, cosmetics
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